Oprah Winfrey has switched talent agencies and signed with Ari Emanuel, the Hollywood agent brother of Mayor Rahm Emanuel and the inspiration for Jeremy Piven's "Entourage" character, Ari Gold.

Winfrey's Chicago-founded production company Harpo also signed with Emanuel agency WME, according to The Hollywood Reporter. The move came a week after the Queen of Daytime's interview with Lance Armstrong, which was watched by 28 million people.